International Journal of Dental Sciences & Research - Volumes & Issues - Volume 1: July 2021, Issue 1

The effect of periodontal therapy on serum c-reactive protein & hba1c levels in chronic periodontitis patients with or without type 2 diabetes mellitus: a clinico biochemical study

Authors

Dr Santokh Singh, Dr Girinandini Singh, Dr Vikram Bali, Dr Gagandeep Gupta, Dr Rajnesh Parimoo, Dr Prabha Choudhary

DOI Number

Keywords

Periodontitis, CRP, Diabetes Mellites

Abstract

Objectives: The purpose of this study was to analyse The Effect of Periodontal Therapy on Serum C-Reactive Protein & HbA1c Levels in Chronic Periodontitis Patients with or without type 2 diabetes melitus : A Clinico Biochemical Study

Study Design: A cohort of thirty subjects, 15 with diabetes and moderate to severe periodontitis & 15 without diabetes and moderate to severe periodontitis were recruited. Periodontal parameters were measured, and blood samples were obtained to evaluate C-reactive protein. Group 1 & 2 were treated with periodontal therapy.

Results:Levels of Serum C-Reactive Protein were highest in chronic Periodontitis and T2DM group. Periodontal clinical parameters PI, GI, PPD, CAL were recorded higher in chronic periodontitis and T2DM group when compared to when healthy participants who have chronic periodontitis. A statistically significant correlation between parameters such as HbA1c, PI, GI, PPD, CAL and CRP was seen.

Conclusions:The results showed a decrease in the levels of C-Reactive & HbA1c after periodontal therapy

References

  1. Genco R, Kornman K, Williams R, et al. Consensus report Periodontal diseases: Pathogenesis and microbial factors. Ann Periodontol1996;1:926-32
  2. Ref Ide M., et al (2003): Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. J Clin Periodontol ; 30: 334-40.
  3. Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, Taylor R. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55(1):21-31.
  4. Ref Williams R.C. and Offenbacher S. (2000): Periodontal Medicine : the emergency of a new branch of periodontology. Periodontology 2000; 23: 9-12.
  5. Ide M, Mc Partlin D, Coward Py, Crook M, Lumb P, Wilson RF. Effect of treatment of chronic periodontitis on levels of serum markers of acute phase inflammatory and vascular responses. J.clinperiodontol 2003; 30: 334-340.
  6. Pepys M.B. (1981): C-reactive protein fifty years on. Lancet; 21: 653-56.
  7. Shah PK. Chronic infection and atherosclerosis/ thrombosis. current artherosclerosis Reports. 2002; 4: 113 119.
  8. Ebersole JL, Maclen RL, Steffen MT, Williman DE. Systemic acute increased have reactants C-reative protein and haptoglobin in adult periodontitis. Clin. Exp. Immunol, 1997; 107: 347-352.
  9. Temelkova-Kurktschiev T, Henkel E, Koehler C, Karrei K, Hanefeld M: Subclinical inflammation in newly detected type II diabetes and impaired glucose tolerance. Diabetologia 45:151, 2002.
  10. Ford ES: Body mass index, diabetes, and C-reactive protein among U.S. adults. Diabetes Care 22:1971–1977, 1999.
  11. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM: C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:327–334, 2001.
  12. Barzilay JI, Abraham L, Heckbert SR, Cushman M, Kuller LH, Resnick HE, Tracy RP: The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study. Diabetes 50:2384–2389, 2001.
  13. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J clin Investigation 2003; 111: 1805 – 1812.
  14. Noack B, Genco RY, Trevisan M, Grossi S, Zamban J, De Nardin E. periodontal infections contribute to elevated systemic C-reactive protein level. J periodontal 2001; 72. 1221 – 1227.
  15. 15. Lagrand WK, Visser CA, Hermens WT. C-reactive protein as a cardiovascular risk factor: More than an epiphenomena. Circulation 1999; 100. 96 – 102

How to cite

Journal

International Journal of Dental Sciences & Research

ISSN

-

Periodicity

Bi-Annual