International Journal of Dental Sciences & Research - Volumes & Issues - Volume 4: Dec 2024,Issue 2

PRF TECHNIQUE AND ASSOCIATED GROWTH FACTORS

  • Published: Dec 2024
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Authors

Vikram Bali, Gagandeep, Rajneesh Parimoo, Rohit Gupta

DOI Number

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Keywords

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Abstract

Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates geared to simplified preparation without bio- chemical blood handling. In this initial article, we describe the conceptual and technical evolution from fibrin glues to platelet concentrates. The slow polymerization during PRF preparation seems to generate a fibrin network very similar to the natural one. Such a network leads to a more efficient cell migration and proliferation and thus cicatrisation DuringPRF processing by centrifugation, platelets are activated and their massive degranulation implies a very significant cytokine release. PRF pro- cessing leads to the intrinsic incorporation of platelet cytokines and glycanic chains in the fibrin meshes. This result would imply that PRF, unlike the other platelet concentrates, would be able to progressively release cytokines during fibrin matrix remodeling; such a mechanism might explain the clinically observed healing properties of PRF.

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International Journal of Dental Sciences & Research

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