The current study examined the relationship between occupational self-efficacy and neuroticism among Omani workers, with an emphasis on whether demographic variables like gender and work experience influenced this relationship. Standardized self-report questionnaires were used in a quantitative, cross-sectional design to gather data from a convenience sample of 67 workers from various companies in Oman. The Big Five Inventory’s Neuroticism subscale (BFI-44; John & Srivastava, 1999) was used to measure neuroticism, while the Occupational Self-Efficacy Scale (Schyns &Von Collani, 2002) was used to measure occupational self-efficacy. Employees with higher neuroticism scores expressed less confidence in handling activities connected to their jobs, according to the results, which showed a significant, moderate, negative association between neuroticism and occupational self-efficacy (r = –0.327, p =.0068). This link was further substantiated by regression analysis (β = –0.747, p =.007), which explained 10.7% of the variance in occupational self-efficacy. Gender (p =.209) and work experience (p =.899) did not significantly affect this connection, according to moderation analyses. These results demonstrate the psychological processes via which personality traits impact workplace functioning and imply that employees with greater levels of neuroticism may benefit from therapies targeted at improving emotional regulation and self-efficacy.