Wet mount microscopy employs water as a mounting medium for viewing the living micro-organisms of different kind. The refractive index of water not only enhances the image quality but also produces image in natural color with no or little artifacts. A qualitative observational study was done in which wet mount slide of the formalin fixed skeletal muscle from the human cadaver was prepared and examined under light microscope. The images showed very fine striated sarcomeric pattern in myofibrils with quiet resemblance to the ultra-structure. The study was helpful in the better comprehension of histological structure of skeletal muscle and gave prevision for further melioration and application in the field of anatomy.
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